COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults
نویسندگان
چکیده
منابع مشابه
COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults.
The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene may be related to individual differences in cognition, likely via modulation of prefrontal dopamine catabolism. However, the available studies have yielded mixed results, possibly in part because they do not consistently account for other genes that affect cognition. We hypothesized that COMT Met allele homozygosity, whi...
متن کاملNo evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.
OBJECTIVE Previous studies linking the catechol O-methyltransferase (COMT) functional polymorphism to the specific phenotype in 22q11.2 deletion syndrome (22q11.2DS) have yielded inconsistent results. The goal of the present study was to replicate a recent finding that executive function is higher in individuals hemizygous for the Met allele. METHOD Thirty-four children and young adults with ...
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OBJECTIVES Although the Val(158)Met catechol-O-methyltransferase (COMT) gene has been linked with the temperament dimension Novelty Seeking (NS), new insights in this polymorphism might point to a major role for character features as well. Given that individual life experiences may influence Val(158) and Met(158) allele carriers differently it has been suggested that the character trait coopera...
متن کاملNo Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women
We examined the effect of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (rs4680), on brain structure in a subset (N = 82) of general population members of the Northern Finland 1966 Birth Cohort, selected through a randomization procedure, aged 33-35. Optimised voxel-based morphometry was used to produce grey matter maps from each subject's high resolution T1 weighted brain magn...
متن کاملIndividual Differences in Executive Function and Phonological Processing: Implications
It is well established that people differ considerably in their ability to learn new languages, especially in the area of phonological processing. Recent research investigating individual differences in phonological processing suggest that factors other than well-studied predictors of success in L2 speech learning, such as age of onset of L2 learning or input quality and quantity, may be at the...
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ژورنال
عنوان ژورنال: Journal of the International Neuropsychological Society
سال: 2010
ISSN: 1355-6177,1469-7661
DOI: 10.1017/s1355617710001402